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The process optimization for AAV harvest contributes to high product recovery, small volumes, reduced host cell impurities and increased full/empty capsid ratio to address time and capacity gaps.
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Proof-of-concept of exosomes manufacturing in scale-X™ bioreactor to demonstrate advantages of intensified and integrated platforms
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Innovative, scalable-by-design fixed-bed technology addresses limitations associated with stirred-tank bioreactors – Tech transfer study by CDMO Exothera
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The scale-X™ bioreactors’ design and performance features allow for linear predictability for process parameter scale-up
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Achieve your goal in biological processes by improving development troubleshooting, focusing on root cause analysis.
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Achieve 3-fold increase in AAV-2 cell-specific productivity using a suspension HEK293F cell line in the scale-X™ structured fixed-bed bioreactor
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Implementation of a metabolite-based cell density estimation and evaluation of harvest strategies for Lentivirus production with HEK293T cells
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Meet capacity challenges growing a suspension HEK293 cell line in serum-free conditions to produce an AAV-2 product in high quantities with a scale-X™ fixed-bed bioreactor
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Recirculation and perfusion are two advantageous methods for supplying medium nutrients to the cells in the scale-X™ structured fixed-bed bioreactor and for harvesting the cell-mediated product.
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Case study for HEK293 cell harvest from fixed-bed fibers
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The role of intensification and integration in rapid deployment of large viral production capacity
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Streamlined bioreactor-to-bioreactor seed train
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Highly productive lentivirus manufacture using the scale-X™ technology
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Scalable and high-productivity manufacture of advanced therapies
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Achievement of large-scale, cost-efficient enzymatic cell collection from structured fixed-bed bioreactors to facilitate and de-risk seed train generation
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Redefining the concepts of scale and flexibility
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Static cell cultivation and production process transferred to the scale-X™ hydro bioreactor.
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Novel approach allows for real-time measurement of cell density in fixed-bed bioreactors
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Our Product Manager Clément Dumont explains how an innovative fixed-bed small-scale parallel system will revolutionize process design & optimization steps resulting in an increased production capacity & quality.
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Addressing biomanufacturing challenges through flexible platform design for both adherent & suspension cell lines
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Decouple process from technology for gene therapy manufacture
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Shake flask process transferred in a scale-X hydro fixed-bed bioreactor for Adenovirus production with HEK293 cells adapted to suspension.
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Process optimization and scale-up from static flask to scale-X bioreactor with 30 m² cell growth surface.
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Intensified and automated dual platform for increased flexibility in viral vector manufacture
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Direct process reproduction from multi-layer bioreactor and roller bottles for four vaccine antigens using three different cell lines (CEF, WI-38 and Vero cells)
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Univercells Technologies provides reliable service solutions and quality support & maintenance to help you maintain performance and maximum safety of the equipment.
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The scale-X hydro bioreactor is a small-scale, single-use, structured fixed-bed bioreactor enabling direct process transfer from existing processing technology for rapid proof of concept within a reduced footprint.
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Case study comparing adherent Vero cell growth on microcarriers and intensified, fixed-bed scale-X bioreactors hydro (2.4 m²) and carbo (10-30 m²). Results demonstrate the scale-X bioreactors as a suitable alternative to traditional technologies.
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The NevoLine™ Upstream system is a high-performance and automated platform for commercial virus manufacturing. It integrates all process steps from inoculation to midstream processing to deliver a ready for downstream bulk.
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Proof of concept for scalable adherent cell growth and adenovirus production
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