Simplifying seed train: a benchtop system for intensified inoculation of large-scale bioreactors

Intensify the inoculation of large-scale bioreactors with a new seed train benchtop module. Discover a CDMO’s experience using the module for low-risk and cost-effective viral production.

The use of adherent-cell cultures for commercial manufacture of advanced therapies requires inoculating large-scale bioreactors with vast amounts of cells.

Traditional cell-expansion systems such as plastic flatware are still used for this purpose, however generally associated with significant aseptic risk, footprint, and production costs.

Univercells Technologies has designed a novel benchtop solution to tackle these challenges, delivering reliable, automated, and intensified seed train.

Discover how a CDMO has used this new technology, achieving harvest cell densities of above 2×109 cells/m² with >90% cell detachment in a small-footprint, low-risk, and cost-effective seed train process.

Learning points

  • Challenges of generating seed train for large-scale manufacture of advanced therapy medicinal products with adherent cells
  • The concept of bioreactor-to-bioreactor seed train, and the possibility of detaching over 90% of cells immobilized in a fixed-bed bioreactor through mechanical and enzymatic action
  • How a new benchtop module enables intensified and reliable seed train generation for industrial bioreactors, providing drastic footprint and cost savings compared to traditional technologies

Watch the webinar on-demand

About our expert

With several years of experience in product management, Clément Dumont is now applying his expertise to the expansion of the scale-X portfolio at Univercells Technologies. Having acquired knowledge in the fields of bioprocess development, characterization, optimization, and medical devices, he helps develop intensified bioreactor systems and innovative process analytical technologies.

Subscribe to
our newsletter