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Achievement of large-scale, cost-efficient enzymatic cell collection from structured fixed-bed bioreactors to facilitate and de-risk seed train generation
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Redefining the concepts of scale and flexibility
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Static cell cultivation and production process transferred to the scale-X™ hydro bioreactor.
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Novel approach allows for real-time measurement of cell density in fixed-bed bioreactors
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Our Product Manager Clément Dumont explains how an innovative fixed-bed small-scale parallel system will revolutionize process design & optimization steps resulting in an increased production capacity & quality.
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Addressing biomanufacturing challenges through flexible platform design for both adherent & suspension cell lines
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Decouple process from technology for gene therapy manufacture
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Shake flask process transferred in a scale-X hydro fixed-bed bioreactor for Adenovirus production with HEK293 cells adapted to suspension.
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Process optimization and scale-up from static flask to scale-X bioreactor with 30 m² cell growth surface.
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Intensified and automated dual platform for increased flexibility in viral vector manufacture
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Direct process reproduction from multi-layer bioreactor and roller bottles for four vaccine antigens using three different cell lines (CEF, WI-38 and Vero cells)
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Univercells Technologies provides reliable service solutions and quality support & maintenance to help you maintain performance and maximum safety of the equipment.
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The scale-X hydro bioreactor is a small-scale, single-use, structured fixed-bed bioreactor enabling direct process transfer from existing processing technology for rapid proof of concept within a reduced footprint.
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Case study comparing adherent Vero cell growth on microcarriers and intensified, fixed-bed scale-X bioreactors hydro (2.4 m²) and carbo (10-30 m²). Results demonstrate the scale-X bioreactors as a suitable alternative to traditional technologies.
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The NevoLine™ Upstream system is a high-performance and automated platform for commercial virus manufacturing. It integrates all process steps from inoculation to midstream processing to deliver a ready for downstream bulk.
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Proof of concept for scalable adherent cell growth and adenovirus production
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The scale-X™ carbo system is a bench-scale automated cell culture system for expression and concentration of viral drug substance, suited for rapid process development and cost-effective clinical production.
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