Addressing large scale inoculation bottlenecks by intensifying and automating the seed train
Case study for HEK293 cell harvest from fixed-bed fibers
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Scalable seed train intensification and automation for adherent cell cultures with the scale-X™ bioreactor
Achievement of large-scale, cost-efficient enzymatic cell collection from structured fixed-bed bioreactors to facilitate and de-risk seed train generation
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A Rapid Fixed-Bed Proof-of-Concept Bioreactor
Static cell cultivation and production process transferred to the scale-X™ hydro bioreactor.
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Integrated continuous biomass estimation in fixed-bed bioreactors
Novel approach allows for real-time measurement of cell density in fixed-bed bioreactors
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Suspension-based viral vector production in scale-X fixed-bed bioreactor
Shake flask process transferred in a scale-X hydro fixed-bed bioreactor for Adenovirus production with HEK293 cells adapted to suspension.
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Scalable rubella production in scale-X™ bioreactor with MRC-5 cells
Process optimization and scale-up from static flask to scale-X bioreactor with 30 m² cell growth surface.
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Successful process transfer of vaccine candidates in scale-X™ hydro bioreactor
Direct process reproduction from multi-layer bioreactor and roller bottles for four vaccine antigens using three different cell lines (CEF, WI-38 and Vero cells)
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Promising Vero cell growth in scale-X™ bioreactors
Case study comparing adherent Vero cell growth on microcarriers and intensified, fixed-bed scale-X bioreactors hydro (2.4 m²) and carbo (10-30 m²). Results demonstrate the scale-X bioreactors as a suitable alternative to traditional technologies.
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Homogenous HEK293 cell growth in scale-X™ bioreactor
Proof of concept for scalable adherent cell growth and adenovirus production
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