NevoLine™ Upstream platform

Evolving biomanufacturing technology

The NevoLine™ Upstream platform is an innovative biomanufacturing technology that delivers cost-effective viral production. This new generation platform builds on the successful NevoLine™ sIPV  proof-of-concept designed to deliver affordable inactivated polio vaccine.

The high-performance, intensified platform features a flexible design to accommodate viral vaccine, gene therapy, and oncolytic virus production. With the NevoLine™ Upstream platform, automated GMP clinical and commercial-scale upstream production is achieved within a 3 m² footprint.

NevoLine Upstream - intensified and automated virus manufacturing - Univercells Technologies

Applications

Viral vectors

Viral vaccines

Oncolytic viruses

Exosomes

Adherent cells

Suspension cells

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Redefining upstream virus production

The NevoLine™ Upstream platform accommodates all unit operations from inoculation to clarification and concentration within a compact module.

Pre-defined single-use assemblies can be selected and combined to meet your process requirements.

Features

Integrating the scale-X nitro bioreactor for commercial production

The scale-X nitro bioreactor enables commercial-scale production in a compact size while offering 200 m² or 600 m² surface for cell growth.

The structured fixed-bed design enables a linear scale-up from the scale-X carbo. As part of the NevoLine Upstream, the bioreactor benefits from the automation and integration offered by the platform.

scale-X-nitro-200-600-m²-growth-surface-single-use-intensified-bioreactor-with-structured-fixed-bed-Univercells-Technologies

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An integrated solution designed for flexibility

NevoLine Upstream - intensified and automated virus manufacturing - Univercells Technologies3
Compact, ergonomic hardware design
Automated bioprocess control
Integrated scale-X™ nitro single-use fixed-bed bioreactor
Single or multi-step clarification
Single-use continuous or sequential tangential flow filtration (TFF)
Main specifications & compliance

Benefits

High Performance

Achieving rapid commercial-scale capacity with drastically reduced operational expenditures and footprint.

Reliability

Integrating all unit steps in a compact design with automated operations for reproducible results.

Flexibility

Combining pre-defined single-use assemblies for a multitude of process designs.

Rapid deployment

Building production capacity easily in new or existing facility for rapid market access.

NevoLine Benefits

Downloads

Related Publications

Services & maintenance

Shortcut to your success

Our experienced Bioprocess & Field Services team is available to support you to quickly and efficiently start your development activities. From the installation of the equipment to process training and maintenance, they are committed to provide the support you need.


Interested in the
NevoLine™ Upstream?

Contact

Chemin de la Vieille Cour 56a and b
1400 Nivelles – Belgium

+32 (0)2 318 83 48
Contact us 

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