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Proof of concept developed by Univercells
The NevoLine™ sIPV platform was initially designed and developed by Univercells as part of a $12M Grand Challenges grant awarded by the Bill & Melinda Gates Foundation to deliver affordable inactivated polio vaccine (sIPV). After two years, Univercells introduced the platform after attaining its goals of delivering a very low cost of goods for an sIPV below $0.30 per trivalent dose. Based on this first successful application, Univercells Technologies developed the new generation of the NevoLine™ biomanufacturing product family, the NevoLine™ Upstream platform.
Overcoming the economies of scale paradigm
The NevoLine™ sIPV platform proposes a disruptive approach to achieve cost-effective viral production. The technology combines principles of process intensification, chaining, and automation in self-contained modules to drastically reduce facility footprint, capital, and operational expenditures. The NevoLine™ sIPV is the proof of concept of the NevoLine™ Upstream platform.
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Reinventing commercial-scale viral production
The low footprint NevoLine™ sIPV platform delivers large quantities of bulk product, rapidly building a cost-effective capacity for viral production. The platform is suited for GMP-compliant manufacture from clinical to commercial scale.
Features
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Proof of concept for intensified & automated virus production
Benefits
Reliability
Automated operations increasing reproducibility, in high-safety modules offering application-specific biosafety levels
Rapid Deployment
Building production capacity in new or existing facility for a rapid market access
Cost-effectiveness
Delivering large manufacturing capacities within a small footprint, drastically reducing capital and operational expenditures
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Related Publications
Disruptive micro-facility – developed by Univercells
Poster presents the NevoLine concept to deliver affordable vaccine doses based on sIPV polio vaccine case study.
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The NevoLine™ platform concept – developed by Univercells
Poster illustrates the key features, benefits and applications of the NevoLine concept with the emphasis on the first implementation of this approach – The NevoLine platform for trivalent polio vaccine (sIPV).
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NevoLine™ sIPV platform: proof of concept – developed by Univercells
The NevoLine sIPV platform was designed and developed by Univercells as part of a $12M Grand Challenges grant awarded by the Bill & Melinda Gates Foundation. This proof of concept was developed to deliver affordable inactivated polio vaccine (sIPV) in a low footprint.
Download