New generation NevoLine™ platform for intensified & automated virus manufacturing

The NevoLine™ Upstream Platform for intensified & automated virus manufacturing

  • The new generation NevoLine™ platform redefines upstream processing by integrating virus production, concentration and clarification for streamlined, high-performance virus manufacturing
  • Building upon the successful proof of concept for sIPV manufacture, this flexible platform was designed to overcome the capacity constraints and high costs of manufacture faced by gene therapy and vaccines manufacturers
  • Commercial scale upstream production is achieved within a 3 m² footprint automated equipment for high-performance, cost-effective virus production

A technology evolution

NevoLine Upstream platform intensified and automated viral production Univercells Technologies

Univercells Technologies is introducing the new generation of the NevoLine biomanufacturing product family, the NevoLine Upstream platform.

This high-performance, low-footprint upstream manufacturing platform is suitable for multiple viral applications to support the booming gene therapy market and offer a cost-effective tool for rapid response to emerging infectious diseases. The innovative design aims to revolutionize upstream processing by intensifying and chaining all unit operations from inoculation to midstream processing to deliver a concentrated, clarified bulk.

With the NevoLine Upstream platform, commercial scale upstream production is possible in a 3 m² module, a 3-fold reduction in equipment footprint compared to conventional technologies.

Developed by virus production experts

The NevoLine Upstream platform was designed by virus manufacturing experts to address the needs of gene therapy and vaccine innovators and CDMOs for robust and cost-effective upstream viral vectors manufacturing. The new generation platform builds on the successful proof of concept with the first NevoLine which was specially designed for affordable production of a trivalent Sabin Inactivated Polio Vaccine (sIPV).

In application, the NevoLine sIPV platform demonstrated how the chaining of unit operations could intensify processes for drastic footprint and cost reductions, with the ability to deliver over 500,000 doses per batch below 0.30 EUR/dose, within a 10 m² equipment footprint.

Redefining upstream processing

The NevoLine Upstream platform accommodates all unit operations from inoculation to midstream processing within a compact module and is suited for GMP, clinical and commercial manufacturing of vaccines, gene therapies and oncolytic viruses.

The automated platform offers a flexible solution suited for multiple viral applications by combining single-use assemblies in process-specific configurations.

At the core of the platform is the scale-X™ nitro structured fixed-bed bioreactor, providing up to 600 m² of growth surface. Mammalian cell culture and virus production can be combined with concentration and single or multi-step clarification for intensified and continuous processes that deliver high productivity with drastically reduced operational costs.

NevoLine Upstream platform intensified and automated viral production Univercells Technologies


A flexible solution readily available

Register below to speak with a Univercells Technologies expert and to receive product updates and invitation for the commercial launch end 2020.

Subscribe to
our newsletter